I cannot be entirely sure, but since going to Go Here v44 I have had complete lock ups of the game (except animations) on 3 occasions in 2 different towns when I have an Actor Trailer outside the house. Complete lock ups are extremely rare for me, much more than all out CTD's. So i'm wondering if maybe Gohere has a problem with Actor trailer, perhaps something with sims leaving it or with the door on it. The last occurrence I think a couple of naughty sims were just about to exit before it locked up.
Just something to consider.